Type III hypersensitivity reaction occurs when there is an accumulation of free-floating antigen-antibody complexes in the tissues, and they activate the complement proteins giving rise to an inflammatory response. Dr. Mobeen Syed explains that when immunoglobulin combines with an antigen freely in the body tissues, it causes conformational change, and the Fc side is exposed.
It allows complement to attach and activate. Complement fixation and activation occurs.
C5a ( complement fragment) is chemotactic for neutrophils. Neutrophils degranulates. Lysosomal enzymes are released from the neutrophils and cause damage to the local tissue.
The following topics have discussed in the video:
* Definition of type III hypersensitivity
* Mechanism of type III hypersensitivity
* Role of complement proteins in hypersensitivity
* Role of neutrophils in type III hypersensitivity
* Role of lysosomes in type III hypersensitivity
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